I feel your pain. I've been there while living at an apt, single, working 10 hrs a day. I tried many things.
Drugs may help but drugs alone will not work. I think Gretchen needs to be crate trained. It's will take a while but it can be done.
- start by just doing the things that gets her anxious... Like picking up your keys, or putting your shoes on, or putting your wallet/phone in your pocket.. You need to break the association of those actions with leaving and getting into the bad crate. Reward Gretchen when she is calm.
- Slowly get Gretchen to go in her crate. Use treats and rewards. If you can't get her in there without pulling on her .. then start small... get her within 10 feet of the crate and sitting, 5 feet, inside with door open, inside sitting, inside laying down, inside laying down for a min, 2,5 min ... inside laying down and you walk away for 10 sec, 30 sec, etc.... you get the idea .... it takes baby steps but she will get it and get over her Anxiety with the crate.
Make sure you reward her every time she is calm and does what you ask.
I hope it works out for you and you decide to keep Gretchen. I know it's not easy, many people on the forum have dealt with a SA dog. My wife asked me if I would ever get another Weim after living with one who has (still) SA... I told her heck yes, Weims are the best breed in my mind, even with their "issues". Many of which can be minimized with some basic training and exercise.
My pit/lab mix is the crate destroyer...Not my Weim! The Weim used to stand, pace, poop, & pee in his crate when he was mad that he was left alone. He hasn't been too bad in the crate lately (knocks on wood)!!
The crate on left is the uber crate. We had to get ir for Leila ... Made my Zinger Winger and it's not cheap ... like $350. She still managed to get her jaws around those vertical bars and bend / break 2 .. So I sent the door back to Zinger and they welded 2 1" wide aluminum bars across those vertical bars. She hasn't even tried to bite the bars since.
The crate on the left is Forrest's. I bought it from Pet Smart about 5 years ago and have not been able to find it since. It's a great crate, there is no pan the sides clip down to a plastic base. However, leila was still able to get out of this one!

This next pic shows what Leila can do to a standard wire crate (left). There is a better picture of Forrest's crate on the right.
